Endocrine Abstracts

Spermatozoa generate small amounts of O2°- and NO°. Under physiological condition these compounds exist at very low concentration and the formation of peroxynitrite (ONOO−) appears likely. Peroxynitrite reacts rapidly with proteins, lipids and DNA. Moreover, tyrosine nitration is a widely used marker of peroxynitrite. The nitration of protein residues gives rise to 3-nitrotyrosine which represents a protein modification specific for ONOO− formation in ...